By making the best use of our core technologies of organic synthesis and biotechnology, we are developing active pharmaceutical ingredients (APIs) and their intermediates. In particular, adapting to the current trends in the pharmaceutical industry, we have been focusing on the development of products in the bio-pharmaceutical field. Moreover, we are putting our efforts into developing new materials, such as health food materials, cosmetics, and so on.
Affinity Chromatography Media for Antibody Purification (Protein A Affinity Media)
Osaka Soda developed new protein A resins that are silica-based and agarose-based for purification of monoclonal and polyclonal antibodies. Silica-based resin is designed for fast and easy purification. Agarose-based resin represents excellent alkali stability. Both resins show superior dynamic binding capacity and enable mild pH range elution to prevent antibodies from aggregation due to engineering (and producing) protein A ligands.
Highly Potent Active Pharmaceutical Ingredients (HPAPIs)
A highly potent active pharmaceutical ingredient (HPAPI) is an indispensable substance for the development of anticancer, immunosuppressive, and central nervous system pharmaceuticals, which are currently the hottest areas of drug development.
We opened a new laboratory to develop the high-potency substance in Amagasaki to enter this growing field.
In compliance with Good Manufacturing Practices (GMP), synthesis in a glove box with OEL Category 5 and KG labo with OEL category 4 are available.
Please contact us for early-stage development and/or manufacturing of standard samples for HPAPIs.
Contract Manufacturing of APIs and their intermediates
We have developed organic synthesis technologies, and biotechnologies such as fermentation and genetic engineering have led us to expand our contract manufacturing business for APIs and their intermediates. We have also been supplying the pharmaceutical industry with a wide variety of chiral compounds derived from chiral epichlorohydrin.
We have also been promoting development in the field related to bio-pharmaceutical products and generic drugs.
β-Glucan/Inclusion Compound with β-Glucan
We produce β-1,3-1,6-glucan by black yeast (Aureobasidium pullulans) fermentation. β-1,3-1,6-glucan enhances intestinal peristalsis, intestinal immune activation, and stress hormone reduction. Our powdered β-1,3-1,6-glucan (Aqua β powder) is used as a health food material with excellent water solubility and dispersability. Currently, we aim to develop for application in the cosmetic and medical fields.
Development of β-glucan inclusion complex
Our black yeast β-1,3-1,6-glucan makes it possible to disperse in water by inclusion of poorly water-soluble compounds such as titanium oxide in polymer chains. For example, shikonin, which has long been known as a herbal medicine, can also provide high water dispersability and stability by using this property. Currently, shikonin dispersion is developed as a cosmetic raw material, "WAKI,” and application development is proceeding.
Linoleic Acid Menthol Ester
Osaka Soda developed linoleic acid menthol ester from natural plant-derived ingredients with its own biotechnology and chromatography technique.
Linoleic acid menthol ester inhibits the synthesis of melanin, which causes skin spots or freckles.
(Osaka Soda industrialized this product from the achievements of Osaka Research Institute of Industrial Science and Technology.)